The 22-250 Remington is my favorite cartridge for long range varmint hunting. I usually take a hundred rounds when I am going out in Montana to hunt gophers (Columbia ground squirrel) and I am partial to a 50 grain hollow tip bullet with as much powder as the case will take without sacrificing accuracy. I still like to see a RED MIST when I make a two hundred yard hit! However, due to the large case capacity, the 22-250 can sometimes be difficult to reload efficiently and a reduced powder load will often give better accuracy. Small variations in charge and bullet seating depth can result in significant accuracy differences. Therefore, finding the best load can take a bit of work. However, this chambering has a reputation for outstanding accuracy potential and, for the serious hunter; it is still my favorite varmint cartridge.
Also a great cartridge (when there is NO wind) for antelope out to two hundred yards. I use Nosler’s partition bullet for 22-250 Remington in a 60gr. Spitzer with 36.8 grains of H380 powder. But this load was the result of careful testing with the particular gun that I was planning on hunting with. I tried over fifteen different powder loads with three different powders, H380, IMR 4895 and IMR 4350 before I found the load my rife liked. But it was well worth the effort and it did anchor that big old prairie goat in his tracks.
From .22-250 Remington.
(2009. March 1). In Wikipedia, The Free Encyclopedia. Retrieved
23:32, March 13, 2009. from
"The .22-250 started life as a wildcat cartridge developed from the
.250-3000 Savage case necked down to take a .224 caliber bullet. In the
early days of the cartridge there were several different versions
that varied only slightly from one to the next, including one
developed in 1937 by Grosvenor Wotkyns, J.E. Gebby and J.E. Smith
who named their version the 22 Varminter.
The .22-250 is very similar to but slightly outperformed (approx 100 ft/s) by the longer .220 Swift cartridge. However, it is in much wider use and has a larger variety of commercially available factory ammunition than the Swift. This makes it generally cheaper to shoot. The smaller powder load also contributes to longer barrel life, an important factor for high-volume shooters.
In 1937 Phil Sharpe, one of the first gunsmiths to build a rifle for the .22-250 and long time .220 Swift rifle builder, stated "The Swift performed best when it was loaded to approximately full velocity," he wrote, whereas, "The Varminter case permits the most flexible loading ever recorded with a single cartridge. It will handle all velocities from 1,500ft/s up to 4,500ft/s."
Sharpe credited the steep 28-degree shoulder for this performance. He insisted that it kept the powder burning in the case rather than in the throat of the rifle, as well as prevented case stretching and neck thickening. "Shoulder angle ranks along with primer, powders, bullets, neck length, body taper, loading density and all those other features," he wrote. "The .22 Varminter seems to have a perfectly balanced combination of all desirable features and is not just an old cartridge pepped up with new powders."